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Selleck Chemical LLC Lenalidomide S1029-1g
Supplier: Selleck Chemical LLC S10291G
Lenalidomide is a TNF- secretion inhibitor with IC50 of 13 nM in PBMCs Lenalidomide (CC-5013) is a ligand of ubiquitin E3 ligase cereblon (CRBN) and it causes selective ubiquitination and degradation of two lymphoid transcription factors IKZF1 and IKZF3 by the CRBN-CRL4 ubiquitin ligase Lenalidomide promotes cleaved caspase-3 expression and inhibit VEGF expression and induces apoptosis
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