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Apexbio Technology LLC Lenalidomide hydrochloride 1243329-97-6 50mg
Supplier: Apexbio Technology LLC A354750
Lenalidomide hydrochloride is a small-molecule immunomodulator that inhibits TNF- secretion It is designed to modulate immune signaling pathways thereby regulating T cell activation and cytokine production Lenalidomide hydrochloride exerts its biological activity primarily by inhibiting TNF- secretion (IC50 13 nM) enhancing IL-2 and soluble IL-2 receptor (sIL-2R) production and inducing CD28 tyrosine phosphorylation followed by NF- B activation in T cells It also impairs autoubiquitination of cereblon (CRBN) a substrate receptor of the E3 ligase complex affecting downstream protein expression including c-Myc IRF4 and p21(WAF-1) Based on these pharmacological properties lenalidomide hydrochloride holds research potential in oncology and inflammation studies focusing on immune modulation
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