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Abcam Leptomycin B (ethanol solution), Antibiotic, antifungal. Inhibitor of CRM-1 mediated nuclear e x port., 25UG
Supplier: Abcam AB12050125UG
MW 540.7 Da, Purity >95%. Potent inhibitor of CRM-1-mediated (exportin-1) nuclear export. Displays antibiotic, antifungal, and antitumor properties and blocks the cell cycle at G₁ and G₂ phases. Potent inhibitor of nucleo-cytoplasmic translocation of Rev. Also shown to suppress HIV-1 replication in human monocytes (IC₅₀ = 600 pM).
The product is subject to the following: Abcam Restricted Use Statement
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