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Medchemexpress LLC Lerociclib (dihydrochloride) | 2097938-59-3 | 98.5% | 547.52 | 50 MG
Supplier: Medchemexpress LLC HY112272A50MG
Lerociclib dihydrochloride is a potent and selective inhibitor of CDK4/CDK6, with IC50s of 1 nM and 2 nM for CDK4/CyclinD1 and CDK6/CyclinD3, respectively.
- Induces a strong and sustained G1 arrest in CDK4/6 dependent cells.
- Inhibits RB phosphorylation within 1 hour post-treatment.
- Effectively inhibits proliferation in various tumor cell lines including breast, melanoma, leukemia, and lymphoma.
- Shows tumor regression in HER2+ breast cancer models.
- Demonstrates tumor growth inhibition in NSCLC tumor models.
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