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Apexbio Technology LLC Lestaurtinib 111358-88-4 5mg
Supplier: Apexbio Technology LLC A45135
Lestaurtinib (CAS 111358-88-4) is a potent selective inhibitor targeting receptor tyrosine kinases FLT3 and TrkA as well as the Janus kinase 2 (JAK2) It demonstrates inhibitory activity against JAK2 FLT3 and TrkA with IC values of approximately 0 9 nM 3 nM and 25 nM respectively By inhibiting these kinases lestaurtinib effectively suppresses downstream STAT5 phosphorylation (IC 20 30 nM) subsequently impeding cellular proliferation at nanomolar concentrations (IC 30 100 nM in HEL92 1 7 cells) It represents a valuable research tool in studies of kinase signaling pathways and myeloproliferative disorders
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