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Apexbio Technology LLC Leucovorin Calcium 6035-45-6 10mM (in 1mL H2O)
Supplier: Apexbio Technology LLC A24895.1
Leucovorin Calcium (CAS 6035-45-6) is a biologically active calcium salt form of folinic acid functioning primarily as a reduced folate derivative It bypasses the inhibitory effects of methotrexate (MTX) on dihydrofolate reductase thus restoring tetrahydrofolate pools and stabilizing DNA synthesis pathways blocked during antifolate therapy Research using human lymphoid cell lines (e g LAZ-007 RAJI) indicates leucovorin calcium selectively decreases sensitivity to MTX-induced growth suppression Due to its mechanism it serves as a valuable reagent in functional assays exploring folate metabolism antifolate drug resistance and mitigation strategies against MTX cytotoxicity
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