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Apexbio Technology LLC LGX818 1269440-17-6 5mg
Supplier: Apexbio Technology LLC B11745
LGX818 (CAS 1269440-17-6) is a selective inhibitor of RAF kinase specifically targeting the B-Raf V600E mutant This mutation causes constitutive activation of B-Raf kinase contributing to cancer progression LGX818 selectively inhibits ERK phosphorylation (EC50 3 nM) and suppresses cell proliferation (EC50 4 nM) in BRAF V600E-expressing A375 melanoma cells displaying minimal activity towards wild-type B-Raf In melanoma xenograft models oral administration of LGX818 significantly reduces MEK phosphorylation leading to tumor regression LGX818 is utilized in cancer research as a tool for studying mutant B-Raf-driven signaling pathways
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