Medchemexpress LLC Licochalcone B | 58749-23-8 | 286.28 | 1 MG

Supplier:  Medchemexpress LLC HYN03731MG

Licochalcone B is an extract from the root of *Glycyrrhiza uralensis*. It inhibits amyloid β (42) self-aggregation (IC50=2.16 μM) and disaggregates pre-formed Aβ42 fibrils. It also reduces metal-induced Aβ42 aggregation by chelating metal ions. Licochalcone B inhibits the phosphorylation of NF-κB p65 in the LPS signaling pathway, inhibits the growth and induces apoptosis of NSCLC cells, and specifically inhibits the NLRP3 inflammasome by disrupting NEK7‐NLRP3 interaction.

• Inhibits amyloid β (42) self-aggregation and disaggregates pre-formed Aβ42 fibrils.
• Reduces metal-induced Aβ42 aggregation through chelating metal ions.
• Inhibits phosphorylation of NF-κB p65 in the LPS signaling pathway.
• Inhibits growth and induces apoptosis of NSCLC cells.
• Specifically inhibits the NLRP3 inflammasome by disrupting NEK7‐NLRP3 interaction.
• Purity: 99.91%.

Catalog No. 50-003-88539