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Medchemexpress LLC Licochalcone D | 144506-15-0 | 1 MG
Supplier: Medchemexpress LLC HYN41871MG
Licochalcone D, a flavonoid compound mainly existing in the root of Glycyrrhiza uralensis, is a potent and orally active inhibitor of NF-kappaB (NF-κB) p65. Licochalcone D possesses antioxidant, anti-inflammatory, and anti-cancer properties.
- Potent and orally active inhibitor of NF-kappaB (NF-κB) p65
- Exhibits antioxidant, anti-inflammatory, and anti-cancer properties
- Negatively regulates LPS-induced NF-κB activation
- Inhibits LPS-induced expression of TNFα and MCP-1
- Inhibits LPS-induced iNOS expression and NO production
- Inhibits the proliferation of human melanoma cells
- Induces apoptosis of A375 cells
- Decreases mitochondrial membrane potential and increases ROS production
- Decreases the migration and invasion ability of A375 cells
- Inhibits tumor growth in a mouse xenograft model of murine melanoma cells
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