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ABclonal Technology LIM kinase 1LIMK1 Rabbit mAb
Supplier: ABclonal Technology A23948100UL
LIMK1 encodes a serine/threonine kinase in the LIM kinase family characterized by two N-terminal LIM domains and a C-terminal kinase domain LIM domains which contain zinc fingers mediate protein-protein interactions LIMK1 regulates actin cytoskeletal dynamics by phosphorylating and inactivating cofilin an actin-binding protein It is ubiquitously expressed during development and is involved in cellular processes such as cytoskeletal organization and axon growth LIMK1 may also contribute to brain development and its hemizygous deletion is linked to impaired visuospatial cognition in Williams syndrome Alternative splicing produces multiple isoforms
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