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Apexbio Technology LLC Lipoamide 940-69-2 500mg
Supplier: Apexbio Technology LLC B7898500
Lipoamide (CAS 940-69-2) is an amide derivative of -lipoic acid acting as a coenzyme for -oxo-acid dehydrogenase complexes It is designed to facilitate acyl and hydrogen group transfer during oxidative decarboxylation and to modulate mitochondrial biogenesis via the NO synthase-cGMP-protein kinase G pathway Lipoamide exerts its biological activity primarily through activation of endothelial nitric oxide synthase enhancing cGMP production and stimulating mitochondrial biogenesis by increasing mitochondrial mass DNA copy number and biogenesis-related transcription factors In post-ischaemic rat myocardium studies lipoamide improves lactate utilization and activates pyruvate dehydrogenase Based on these pharmacological properties lipoamide holds research potential in cell metabolism studies enhancement of mitochondrial function and ischemic injury research
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