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Medchemexpress LLC Liquiritigenin | 578-86-9 | 256.25 | 50 MG
Supplier: Medchemexpress LLC HYN037750MG
Liquiritigenin is a flavanone isolated from *Glycyrrhiza uralensis*. It functions as a highly selective estrogen receptor β (ERβ) agonist, with an EC50 of 36.5 nM for activating ERE tk-Luc. This compound is intended for research use only.
- Acts as a selective estrogen receptor β (ERβ) agonist (EC50 of 36.5 nM).
- Activates ERE tk-Luc in U2OS cells transfected with ERβ.
- Recruits steroid receptor coactivator-2 (SRC-2) to target genes in ERβ cells.
- Prevents methylglyoxal-induced cell death in MC3T3-E1 cells.
- Reduces pro-inflammatory cytokines in serum and hippocampus in vivo.
- Does not stimulate uterine size or tumorigenesis of MCF-7 breast cancer cells in vivo.
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