Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. 5000440076

Medchemexpress LLC Cholan-24-oic acid, 3-[(2S)-2-amino-3-carboxy-1-oxopropoxy]-, (3α,5β)- | 881179-02-8 | 98.0% | 491.66 | 25 MG
SDP

Supplier:  Medchemexpress LLC 25MGHY112415

Encompass_Preferred

Lith-O-Asp is a sialyltransferase (ST) inhibitor, with IC50 values ranging from 12-37 μM against ST3Gal I, ST3Gal III, and ST6GalI. It inhibits α-2,3- and α-2,6-sialyltransferases, decreasing sialic acid transfer to targeted glycoproteins. Research shows potential in suppressing cancer angiogenesis and metastasis, with treated mice exhibiting fewer lung metastases in a 4T1-Luc breast cancer model.

  • Sialyltransferase (ST) inhibitor
  • IC50 values of 12-37 μM against ST3Gal I, ST3Gal III, and ST6GalI
  • No apparent growth inhibition effect on different cancer cell lines at tested doses (10, 30, and 60 μM)
  • Decreases expression of cell surface α-2,3- and α-2,6-sialylated antigens
  • Suppresses FAK/paxillin signaling and cancer angiogenesis and metastasis pathways in vivo

Catalog No. 50-004-40076


May include imposed supplier surcharges.
Only null left
Add to Cart

Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.