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Medchemexpress LLC Lithocholic acid | 434-13-9 | 100.0% | 1 ML
SDP

Supplier:  Medchemexpress LLC HYB017210MM/1ML

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Lithocholic acid is a toxic secondary bile acid that can promote intrahepatic cholestasis and tumorigenesis. It is also an FXR antagonist and a PXR/SXR agonist.

  • Toxic secondary bile acid
  • Promotes intrahepatic cholestasis
  • Promotes tumorigenesis
  • FXR antagonist
  • PXR/SXR agonist
  • Can be used to induce cholestasis models
  • Inhibits CDCA- and GW4064-induced FXR activation with IC50s of 0.7 and 1.4 μM, respectively (in vitro)
  • Inhibits 100 nM GW4064 induced BSEP expression in HepG2 cells (10-30 μM, 24 h) (in vitro)
  • Dose-dependently inhibits the proliferation of neuroblastoma cells (BE(2)-m17, SK-n-SH, SK-n-MCIXC and Lan-1) (0-500 μM) (in vitro)

Catalog No. 50-004-05354


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