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Apexbio Technology LLC LJI308 1627709-94-7 2mg
Supplier: Apexbio Technology LLC B60432
LJI308 (CAS 1627709-94-7) is a potent and selective small-molecule inhibitor of p90 ribosomal S6 kinases (RSK1 RSK2 RSK3) with reported IC50 values ranging from 0 004 to 0 013 mM By targeting RSK kinases downstream effectors in the ERK/MAPK pathway LJI308 modulates signaling processes involved in cell survival proliferation and polarity In cellular assays LJI308 demonstrates concentration-dependent inhibition of colony formation and cell growth in cancer cell lines such as MDA-MB-231 and H358 while exerting minimal effects on non-tumorigenic cells LJI308 is utilized in studies exploring RSK signaling chemoresistance and the elimination of cancer stem cells particularly in triple-negative breast cancer models
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