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Medchemexpress LLC Lom612 | 2173232-79-4 | 98.9% | 258.30 | C13H10N2O2S | 25 MG
SDP

Supplier:  Medchemexpress LLC HY10103525MG

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LOM612 is a small-molecule FOXO relocator that promotes nuclear translocation of FOXO transcription factors (FOXO1, FOXO3a) and increases expression of FOXO target genes such as p27 and FasL. It is active in cellular assays (U2fox RELOC) with an EC50 of 1.5 μM and shows cytotoxicity to HepG2 cells (IC50 0.64 μM). Supplied as a solid with high reported purity for research use.

  • Potent FOXO relocator with EC50 1.5 μM in U2fox RELOC cells.
  • Induces nuclear translocation of FOXO1 and FOXO3a and upregulates p27 and FasL.
  • Shows cytotoxicity to HepG2 cells (IC50 0.64 μM) with lower activity in THLE2 cells.
  • High reported purity (98.85%) and solid, pink to red appearance.
  • Soluble in DMSO at 1 mg/mL with recommended warming and sonication; follow storage instructions.

Catalog No. 50-002-12024


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