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Medchemexpress LLC Lopinavir | 192725-17-0 | 99.7% | C37H48N4O5 | 250 MG
Supplier: Medchemexpress LLC 250MGHY14588
Lopinavir is a highly potent, selective peptidomimetic inhibitor of HIV-1 protease, effective against both wild-type and mutant forms with Ki values of 1.3 to 3.6 pM. It blocks HIV-1 infectivity by arresting its maturation. This compound also functions as a SARS-CoV 3CLpro inhibitor with an IC50 of 14.2 μM, and blocks HIV type 1 replication with an EC50 of 0.006 to 0.017 μM.
- Highly potent and selective peptidomimetic inhibitor of HIV-1 protease.
- Effective against both wild-type and mutant HIV protease.
- Blocks HIV-1 infectivity by arresting its maturation.
- Also acts as a SARS-CoV 3CLpro inhibitor.
- Pharmacokinetic properties and activity against HIV-1 protease are improved when coadministered with low-dose ritonavir.
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