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Cayman Chemical Losartan potassium salt
Supplier: Cayman Chemical 1000659450 MG
An AT1b antagonist (IC50 = 2.2 nM in COS-7 cells expressing the rat receptor); reduces U-46619-induced aggregation of platelets in isolated human platelet-rich plasma at 5 µM; decreases 1-LO levels in the endothelial layer of autologous vein grafts in rabbits fed a high-cholesterol diet at 10 mg/kg per day; decreases systolic blood pressure in a ouabain-induced mouse model of hypertension at 15 mg/kg per day; increases the mechanical pain threshold in the von Frey test in a paclitaxel-induced rat model of neuropathic pain at 50 mg/kg twice per day
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