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Cayman Chemical Losartn Carboxaldehyde 10mg
Supplier: Cayman Chemical 1885510 MG
An active metabolite of losartan; inhibits arachidonic acid-induced platelet aggregation in isolated human platelet-rich plasma at 10 pM; a PPARγ agonist (EC50 = 17.1 µM in COS-7 cells expressing human PPARγ using a reporter assay); increases lipid accumulation in 3T3-L1 adipocytes at 10 µM; decreases superoxide production by NOX in isolated human PBMCs in a concentration-dependent manner; inhibits LPS-induced increases in COX2 mRNA expression and LPS- or angiotensin II-induced increases in supernatant PGF2α levels in HUVECs at 10 µM
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