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Apexbio Technology LLC Loxapine 1977-10-2 500mg
Supplier: Apexbio Technology LLC B1001500
Loxapine is a dibenzoxazepine derivative functioning as an antagonist at serotonin (5-HT) and dopamine receptors notably displaying high affinity towards 5-HT2 and dopamine D4 receptor subtypes It serves as an inhibitor of serotonin 5-HT2 receptors (human and bovine frontal cortex membranes Ki approximately 6 2-6 6 nM) Additionally Loxapine suppresses dopamine D2 and D4 receptor activities and modulates cytokine release reducing interleukin IL-1 and IL-2 secretion in LPS-stimulated rat glial cell cultures at concentrations ranging from 0 2 to 20 M Given these properties Loxapine is utilized as a pharmacological tool in research exploring serotonergic and dopaminergic signaling pathways relevant to psychiatric disorders and neuroinflammatory processes
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