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Medchemexpress LLC Lp-533401 hydrochloride | 1040526-12-2 | MFCD18803629 | 95.2% | 562.94 | C27H23ClF4N4O3 | 10 MG
Supplier: Medchemexpress LLC HY15849A10MG
LP-533401 hydrochloride is a small-molecule inhibitor of tryptophan hydroxylase 1 (TPH1) used in research to reduce peripheral serotonin production and to study bone and gut serotonin biology. It exhibits potent in vitro inhibition of serotonin synthesis and shows oral efficacy in rodent models with minimal brain penetration.
- Inhibits tryptophan hydroxylase 1 and reduces peripheral serotonin production.
- Potent in vitro activity (complete inhibition reported at 1 μM in Tph1-expressing cells).
- Oral efficacy in rodent models; prevents and rescues osteoporosis in ovariectomized animals.
- Minimal brain penetration, indicating limited blood-brain barrier crossing.
- Light yellow solid with high reported purity.
- Soluble in DMSO (25 mg/mL); practically insoluble in water.
- Available as small solid quantities and as a ready-made solution for research applications.
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