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Medchemexpress LLC Lunresertib | 2719793-90-3 | 100.0% | C18H20N4O2 | 1 ML
Supplier: Medchemexpress LLC HY145817A10MM/1ML
Lunresertib (RP-6306) is a potent, selective, and orally active PKMYT1 inhibitor with an IC50 of 14 nM. It demonstrates high selectivity over other kinases in cellular binding assays and exhibits anticancer effects by inducing pan-γH2AX in HCC1569 breast cancer cell lines, making them vulnerable to DNA damage. Lunresertib also causes unscheduled activation of CDK1 in CCNE1-overexpressing cells, promoting early mitosis.
- Potent and selective PKMYT1 inhibitor
- Orally active with an IC50 of 14 nM
- High selectivity over other kinases in cellular binding assays
- Exhibits anticancer effects
- Induces pan-γH2AX in HCC1569 breast cancer cell line
- Causes unscheduled activation of CDK1 in CCNE1-overexpressing cells
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