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Medchemexpress LLC LX2343 | 333745-53-2 | 474.91 | 100 MG
SDP

Supplier:  Medchemexpress LLC HY11138350MG

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LX2343 is a BACE1 enzyme inhibitor with an IC50 value of 11.43±0.36 μM. It acts as a non-ATP competitive PI3K inhibitor with an IC50 of 15.99±3.23 μM. LX2343 stimulates autophagy in its promotion of Aβ clearance, ameliorating cognitive dysfunction in APP/PS1 transgenic mice via both Aβ production inhibition and clearance promotion, which highlights its potential in the treatment of AD.

  • Dose-dependently decreased Aβ accumulation in HEK293-APPsw and CHO-APP cells.
  • Promotes Aβ clearance in SH-SY5Y cells and primary astrocytes.
  • Antagonizes prolonged path lengths and escape latencies in the MWM test in APP/PS1 mice.

Catalog No. 50-003-43126


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