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Selleck Chemical LLC LY 345899-E1317-5MG
Supplier: Selleck Chemical LLC E13175MG
LY345899 is a Folate analog and a potent inbhibitor of methylene tetrahydrofolate dehydrogenase1 (MTHFD1 DC301) and methylene tetrahydrofolate dehydrogenase2 (MTHFD2) with IC50 values of 96 nM and 663 nM respectively It significantly suppresses tumor growth and reduces tumor weight in CRC patient-derived xenograft models
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