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Selleck Chemical LLC Rabusertib (LY2603618) 5mg 911222-45-2 IC-83
Supplier: Selleck Chemical LLC S26265MG
Rabusertib (LY2603618, IC-83) is a highly selective Chk1 inhibitor with potential anti-tumor activity in a cell-free assay. IC50=7 nM, showing approximately 100-fold more potent against Chk1 than against any of the other protein kinases evaluated. Rabusertib (LY2603618) induces cell cycle arrest, DNA damage response and autophagy in cancer cells. Rabusertib (LY2603618) induces bak-dependent apoptosis in AML cell lines. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
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