Apexbio Technology LLC LY2857785 1619903-54-6 50mg

Supplier:  Apexbio Technology LLC B800250

LY2857785 (CAS 1619903-54-6) is a selective class I reversible ATP-competitive inhibitor of cyclin-dependent kinases CDK9 CDK8 and CDK7 which are involved in transcriptional regulation via phosphorylation of the RNA polymerase II C-terminal domain In preclinical studies LY2857785 reduces XIAP and MCL1 protein levels and decreases RNAP II CTD phosphorylation resulting in apoptosis in hematologic malignancy cell lines including MV-4-11 and various leukemia and solid tumor models It demonstrates antitumor activity in in vivo leukemia models and inhibits the growth of primary AML and CLL samples LY2857785 is a valuable tool for investigating transcriptional kinase pathways and their role in hematologic cancer biology

Catalog No. 50-000-90990