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Medchemexpress LLC N-(3,3-dimethylbutyl)-N'-(2-fluoro-4-methyl-5-(pyrido[2,3-d]pyrimidin-6-yl)phenyl)urea | 1454682-72-4 | MFCD28411374 | >98.0% | 424.52 | C23H29FN6O | 50MG
SDP

Supplier:  Medchemexpress LLC HY1255850MG

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LY3009120 (DP-4978) is an investigational small-molecule pan-RAF kinase inhibitor developed by Eli Lilly. It inhibits A-RAF, B-RAF (including BRAFV600E), and C-RAF, interferes with RAF dimer signaling, and has demonstrated low-nanomolar biochemical potency and antitumor activity in preclinical models and early clinical studies.

  • Pan-RAF inhibition including BRAFV600E, BRAFWT, and CRAFWT
  • Low-nanomolar biochemical potency (reported IC50s: 5.8 nM, 9.1 nM, 15 nM)
  • Activity in BRAF- or RAS-mutant preclinical cancer models
  • Suitable for mechanistic and pharmacology research
  • High purity material suitable for biological assays

Catalog No. 50-202-8891


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