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Medchemexpress LLC LY3522348 (KHK-IN-3) | 2568608-48-8 | 98.3% | 409.41 | 1 ML
SDP

Supplier:  Medchemexpress LLC HY14998710MM/1ML

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KHK-IN-3 (Example 1) is a ketohexokinase (KHK) inhibitor. It can be used in the study of kidney disease, nonalcoholic steatohepatitis (NASH), diabetes, and heart failure. KHK is a rate-limiting enzyme and fructokinase involved in fructose metabolism. KHK catalyzes the phosphorylation of fructose to fructose-1-phosphate (FIP) at the expense of ATP. The lack of feedback inhibition of fructose metabolism triggers the accumulation of downstream intermediates such as lipogenesis, gluconeogenesis, and oxidative phosphorylation.

  • Ketohexokinase (KHK) inhibitor
  • Used in the study of kidney disease
  • Used in the study of nonalcoholic steatohepatitis (NASH)
  • Used in the study of diabetes
  • Used in the study of heart failure
  • Inhibits the rate-limiting enzyme KHK in fructose metabolism
  • Catalyzes phosphorylation of fructose to fructose-1-phosphate
  • For research use only

Catalog No. 50-003-61262


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