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Medchemexpress LLC M-PEG12-DBCO | 96.9% | C44H66N2O14 | 100 MG
Supplier: Medchemexpress LLC HY140317100MG
m-PEG12-DBCO is a PEG-based PROTAC linker used in the synthesis of PROTACs. This click chemistry reagent features a DBCO group that enables strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing azide groups. PROTACs utilizing this linker connect an E3 ubiquitin ligase ligand with a target protein ligand to leverage the intracellular ubiquitin-proteasome system for selective target protein degradation.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Functions as a click chemistry reagent
- Contains a DBCO group
- Enables strain-promoted alkyne-azide cycloaddition (SPAAC) with azide groups
- Facilitates selective degradation of target proteins
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