Bio X Cell Antibody, anti-mouse PD-1 (CD279), Clone RMP1-14, Rat IgG2a

Supplier:  Bio X Cell BE0146R001MG

The RMP1-14 monoclonal antibody targets mouse PD-1 (programmed death-1), also known as CD279. PD-1 is a 50-55 kDa cell surface receptor of the Ig superfamily, negatively regulating TCR signals. It binds PD-L1 and PD-L2, inhibiting T-cell activation, proliferation, and cytokine production, which can lead to T-cell death. The RMP1-14 antibody specifically blocks the binding of both mouse PD-L1-Ig and mouse PD-L2-Ig to PD-1.

• Clone RMP1-14
• Targets mouse PD-1 (CD279)
• Mouse reactivity
• Isotype is Rat IgG2a, κ
• Applications include in vivo blocking of PD-1/PD-L signaling and in vitro organoids/organ-on-chip
• Formulated in PBS, pH 7.0, no stabilizers or preservatives
• Endotoxin is ≤1EU/mg
• Purity is ≥95%
• Sterility via 0.2 μm filtration
• Molecular weight is 150 kDa
• Store at 4°C; do not freeze

Catalog No. 50-152-8351