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Medchemexpress LLC Macrophage-activating lipopeptide 2 TFA | 99.8% | 2135.56 | 1 MG
Supplier: Medchemexpress LLC HYP10586A1MG
Macrophage-activating lipopeptide 2 TFA is an agonist of Toll-like receptors TLR-2/TLR-6. It enhances endothelial nitric oxide synthase (eNOS) phosphorylation and endothelial cell release of NO, which improves vasodilation. It also enhances endothelial adhesion of white blood cells and improves perfusion recovery and collateral growth in the hind limbs of hypercholesterolemic Apoe deficient mice undergoing experimental femoral artery ligation (FAL).
- Promotes expression of major endothelial adhesion molecules
- Enhances leukocyte endothelial adhesion
- Promotes phosphorylation of protein kinase B and eNOS in endothelial MyEnd cells
- Improves hind limb perfusion recovery and collateral growth
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