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Medchemexpress LLC Mal-PEG4-Val-Cit-PAB-PNP | 2112738-09-5 | MFCD30828694 | >98.0% | 871.89 g/mol | C40H53N7O15 | 10 MG
Supplier: Medchemexpress LLC HY14014510MG
Mal-PEG4-Val-Cit-PAB-PNP is a cleavable polyethylene glycol (PEG4) antibody-drug conjugate (ADC) linker containing a maleimide thiol-reactive group, a valine-citrulline protease-cleavable dipeptide, and a para-aminobenzyl self-immolative spacer with a p-nitrophenyl leaving group. It is used in research to attach cytotoxic payloads to antibodies via thiol conjugation and enable intracellular payload release after protease-mediated cleavage.
- Cleavable val-cit dipeptide for protease-triggered payload release.
- Maleimide group for thiol-selective conjugation to cysteine residues.
- PEG4 spacer improves hydrophilicity and solubility.
- PAB self-immolative spacer enables rapid payload liberation after cleavage.
- Available in small pack sizes suitable for research-scale synthesis.
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