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Enzo Life Sciences Manoalide (1mg). CAS: 75088-80-1
Supplier: Enzo Life Sciences BMLEI1770001
Marine sesterterpenoid. Irreversibly inhibits human synovial phospholipase A2 (PLA2, IC50=0.02-0.2µM depending on substrate) as well as bee (IC50=0.05µM) and cobra venom (IC50=2µM) PLA2 by covalently modifying lysine residues. Inhibits human recombinant sPLA2 (IC50=4.7µM) selectively over cPLA2. Also inhibits phospholipase C (PLC, IC50=1.5µM) and Ca2+ channels. Inhibits superoxide generation in polymorphonuclear leukocytes. Inhibits the release of arachidonate in cultured mouse peritoneal macrophages and in a mouse in vivo model. Has anti-inflammatory and analgesic properties. Shows strong quorum sensing antagonism. Purity: ≥98% (TLC). Solubility: Soluble in DMSO (25mg/ml), 100% ethanol (25mg/ml) or methanol. Long Term Storage: -20°C.
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