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Medchemexpress LLC MAO-A/5-HT2AR-IN-1 | 2769156-00-3 | C30H28FN3O2 | 5 MG
Supplier: Medchemexpress LLC HY1515965MG
MAO-A/5-HT2AR-IN-1 is a potent dual inhibitor of MAO-A (IC50: 0.004 μM) and 5-HT2AR (IC50: 0.014 μM), recognized as a potential antidepressant agent. It exhibits significant neurocytoprotective effects in CORT-induced cell depression models and interacts with both targets via hydrogen bonding and π-π stacking. The compound shows low proliferation inhibitory activities against L02, SH-SY5Y, and PC12 cells, indicating a favorable safety profile.
- Improves depression-like behavior in mice.
- Enhances locomotion and depression-like behavior in zebrafish.
- Repairs damage to mouse hippocampal neuronal cells and reduces 5-HT2AR expression.
- Exhibits good clearance rate in rats after intravenous and intragastric administration.
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