Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
Medchemexpress LLC Mardepodect | 898562-94-2 | 98.8% | C25H20N4O | 25 MG
Supplier: Medchemexpress LLC 25MGHY50098
Mardepodect (PF-2545920) is a potent, selective orally active, and brain-penetrant PDE10A inhibitor with an IC50 of 0.37 nM, demonstrating over 1000-fold selectivity over other PDEs. It has shown activity in preclinical models for positive, cognitive, and negative symptoms of schizophrenia and increases striatal cGMP in mice in a dose-dependent manner. This product is for research use only.
- Potent and selective PDE10A inhibitor
- Orally active and brain-penetrant
- IC50 of 0.37 nM
- Exhibits >1000-fold selectivity over other PDEs
- Active in conditioned avoidance response (CAR) assay with an ED50 of 1 mg/kg
- Causes a dose-dependent increase in striatal cGMP in mice
Product Title
By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.
Spot an opportunity for improvement?