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Apexbio Technology LLC MCC950 SODIUM 200MG
SDP

Supplier:  Apexbio Technology LLC B7946200

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MCC950 sodium (CAS 256373-96-3) is a selective small-molecule inhibitor targeting the NOD-like receptor family protein 3 (NLRP3) inflammasome MCC950 sodium inhibits NLRP3 activation in murine bone marrow-derived macrophages (BMDMs) with an IC50 of 7 5 nM and demonstrates comparable selectivity and potency in human monocyte-derived macrophages (HMDMs) It specifically blocks both canonical and noncanonical activation pathways without affecting other inflammasomes such as AIM2 NLRC4 and NLRP1 Due to its selectivity MCC950 sodium is valuable in investigating NLRP3-associated inflammatory and autoimmune conditions

Catalog No. 50-000-60100


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