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Medchemexpress LLC Mefenamic acid | 61-68-7 | 10 G
Supplier: Medchemexpress LLC HYB057410G
Mefenamic acid is a BBB-permeable and non-steroidal anti-inflammatory agent. It acts as a competitive inhibitor of hCOX-1 and hCOX-2, with IC50s of 40 nM and 3 μM for hCOX-1 and hCOX-2, respectively. Mefenamic acid (0-100 μM) has cytotoxic effects on KB, Saos-2, and 1321N cells, however, U-87MG cells are resistant to Mefenamic acid.
- Molecular formula: C15H15NO2
- Molecular weight: 241.29
- Target: COX
- Pathway: Immunology/Inflammation
- Solubility in vitro: DMSO: ≥ 100 mg/mL (414.44 mM), H2O: < 0.1 mg/mL (insoluble)
- Solubility in vivo: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline: 2.5 mg/mL (10.36 mM); 10% DMSO >> 90% corn oil: ≥ 2.5 mg/mL (10.36 mM)
- Storage (powder): -20°C for 3 years, 4°C for 2 years
- Storage (in solvent): -80°C for 2 years, -20°C for 1 year
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