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ABclonal Technology Megalin/LRP2 Rabbit mAb
Supplier: ABclonal Technology A2469020UL
The gene encodes low-density lipoprotein-related protein 2 (LRP2) also known as megalin a multi-ligand endocytic receptor primarily expressed in absorptive epithelial tissues like the kidney This glycoprotein features a large extracellular domain a single transmembrane domain and a short cytoplasmic tail It binds diverse ligands such as albumin apolipoproteins B and E and lipoprotein lipase LRP2 is crucial for reuptaking lipoproteins sterols vitamin-binding proteins and hormones It also participates in cell signaling with extracellular ligands like parathyroid hormone and sonic hedgehog and cytosolic ligands including MAP kinase scaffold proteins Its recycling is regulated by phosphorylation of its cytoplasmic domain Mutations in this gene are linked to Donnai-Barrow syndrome (DBS) and facio-oculoacoustico-renal syndrome (FOAR)
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