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Apexbio Technology LLC Memantine hydrochloride 41100-52-1 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC B33085.1
Memantine hydrochloride (CAS 41100-52-1) is a selective noncompetitive NMDA receptor antagonist Biochemically memantine preferentially inhibits recombinant rat NMDA receptors expressed as NR1a/NR2A NR1a/NR2B and NR1a/NR2D subunits with reported IC50 values of 0 93 M 0 82 M and 0 47 M respectively Studies using HEK293 cells transiently expressing these receptor subunits indicate that this inhibition is voltage- and dose-dependent exhibiting rapid channel unblocking kinetics Clinically memantine is used for Alzheimer s disease Parkinson s disease and spasticity it is additionally investigated in vitro for reducing amyloid-beta toxicity and tau phosphorylation
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