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Medchemexpress LLC MET kinase-IN-4 | 888719-03-7 | 99.0% | 458.42 | 25 MG
Supplier: Medchemexpress LLC 25MGHY18309
MET kinase-IN-4 is an orally active Met kinase inhibitor with potent Met kinase inhibitory activity (IC50 value of 1.9 nM). It can be used for cancer research. It also inhibits Flt-3 and VEGFR-2 kinases with IC50 values of 4 nM and 27 nM, respectively. MET kinase-IN-4 (3 μM) shows good metabolic stability in both human and mouse liver microsomes.
- Orally active Met kinase inhibitor.
- Potent Met kinase inhibitory activity with an IC50 value of 1.9 nM.
- Inhibits Flt-3 and VEGFR-2 kinases with IC50 values of 4 nM and 27 nM, respectively.
- Shows good metabolic stability in both human and mouse liver microsomes.
- Possesses a favorable pharmacokinetic profile in mice.
- Demonstrates significant in vivo antitumor activity in the GTL-16 human gastric carcinoma xenograft model.
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