Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
Cayman Chemical MetamIzolesodIum salt 25g
Supplier: Cayman Chemical 1577125 G
A nonopioid prodrug; inhibits COX-1 and COX-2 activity (IC50 = ~150 UG/ml for both in cell-free assays), as well as reduces AITC-induced increases in intracellular calcium levels in isolated rat and mouse dorsal root ganglia and IMR-90 human fibroblasts (IC50s = 30-91 µM in patch-clamp assays); inhibits ADP- and epinephrine-induced platelet aggregation in hPRP; prevents fever induced by LPS, TNF-α, and IL-6, but not arachidonic acid or PGE2, in rats at 120 mg/kg; increases the paw withdrawal threshold in the paw pressure test in rat models of carrageenan-induced acute pain and postoperative incision pain at 250 and 500 mg/kg
Product Title
By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.
Spot an opportunity for improvement?