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AdipoGen Metformin HCl
SDP

Supplier:  AdipoGen AGCR13689G005

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Chemical. CAS 1115-70-4. Formula C4H11N5 . HCl. MW 129.2 . 36.5. . AMPK activator. Useful agent for immunometabolism research. Reported to stimulate AMP-activated protein kinase AMPK, leading to the reduction in acetyl-CoA carboxylase ACC activity and induction of fatty acid oxidation. Mitochondrial electron transport chin complex I inhibitor, reducing mitochondrial reactive oxygen species ROS. Antidiabetic and anti-hyperglycemic agent that reduces blood glucose levels, improves insulin sensitivity and decreases insulin resistance. Its metabolic effects, including the inhibition of hepatic gluconeogenesis, are mediated in part by activation of the LKB1-AMPK AMP-activated protein kinase pathway. Used as weight-loss agent in obesity and as insulin sensitizer in nonalcoholic fatty liver disease NAFLD. Leptin sensitizer to mediate the weight-loss effect in the brain.

Catalog No. 50-256-2221


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