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Medchemexpress LLC Methanone, [2-fluoro-4-[2-(4-methoxyphenyl)ethynyl]phenyl][(3R)-3-hydroxy-1-piperidinyl] | 1443118-44-2 | 99.1% | 353.39 | 25 MG
SDP

Supplier:  Medchemexpress LLC 25MGHY16636

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ML337 is a selective and brain-penetrant negative allosteric modulator of mGlu3, with an IC50 of 593 nM. It possesses a favorable dystrophia myotonica protein kinase (DMPK) and ancillary pharmacology profile. ML337 is also a click chemistry reagent, containing an Alkyne group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

  • Selectivity: highly selective for mGlu3, with no activity at mGlu1, 2, 4, 5, 6, 7, and 8 at concentrations up to 30 μM.
  • Brain-penetrant: capable of crossing the blood-brain barrier.
  • Dmpk profile: possesses a favorable dystrophia myotonica protein kinase (DMPK) profile.
  • Click chemistry reagent: contains an Alkyne group, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules.
  • Appearance: off-white to light yellow solid.

Catalog No. 50-003-95180


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