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Medchemexpress LLC Methanone, (4-amino-1,3-dihydrofuro[3,4-c]naphthyridin-8-yl)[(3S)-3-[4-(trifluoromethyl)phenyl]-4-morpholiny | 2790567-82-5 | C22H19F3N4O3 | 250 MG
SDP

Supplier:  Medchemexpress LLC 250MGHY153390

Encompass_Preferred

AMG 193 is an orally active MTA-cooperative PRMT5 inhibitor with antitumor activity. When complexed with MTA, it preferentially inhibits the growth of MTAP-deficient tumor cells by inhibiting PRMT5, while protecting normal cells with wild-type MTAP. This compound is for research use only.

  • Preferentially inhibits the growth of MTAP-deficient tumor cells
  • Inhibits PRMT5 with an IC50 of 0.107 μM
  • Protects normal cells with wild-type MTAP
  • Induces alternative splicing defects, cell cycle arrest, and DNA damage response in MTAP-deficient HCT116 cells
  • Reduces S phase and increases G2/M cell population in MTAP-deficient cells
  • Dose-dependently inhibits tumor growth in MTAP-deficient xenograft mice
  • Causes tumor regression in 70% of mice with DLBCL tumors
  • Preserves normal hematopoietic cell lineages

Catalog No. 50-003-74437


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