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Medchemexpress LLC Methanone, [5-chloro-2-[2-(methylamino)-4-thiazolyl]-4-pyridinyl][4-[(4-chlorophenyl)methyl]-1-piperazinyl]- | 2123489-30-3 | 99.7% | 462.40 | 1 ML
SDP

Supplier:  Medchemexpress LLC HY11209410MM/1ML

Encompass_Preferred

WNK-IN-11 is an allosteric With-No-Lysine (WNK) kinase inhibitor, with an IC50 of 4 nM for WNK1.

  • Allosteric With-No-Lysine (WNK) kinase inhibitor.
  • IC50 of 4 nM for WNK1.
  • IC50<2 μM in the cellular OSR1 phosphorylation assay.
  • Reasonable aqueous solubility.
  • ATP noncompetitive inhibition.
  • Excellent selectivity with only a few significant off-target kinase inhibitions (BTK and feline encephalitis virus-related (FER) kinase) when tested against a panel of 440 human kinases at 10 μM concentration.
  • Predicted allosteric binding mode outside the highly conserved ATP-pocket.

Catalog No. 50-004-37562


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