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Medchemexpress LLC Methyl p-coumarate (Methyl 4-hydroxycinnamate) | 3943-97-3 | 178.18 | 10 G
Supplier: Medchemexpress LLC HYN143410G
Methyl p-coumarate (Methyl 4-hydroxycinnamate) is an orally active esterified derivative of p-Coumaric acid (pCA) that can be isolated from the flower of *Trixis michuacana var longifolia*. It has been shown to inhibit melanin formation in B16 mouse melanoma cells and exhibits a strong *in vitro* inhibitory effect on *A. alternata* and other pathogens.
- Inhibits melanin formation in B16 mouse melanoma cells.
- Exhibits strong *in vitro* inhibitory effect on *A. alternata* and other pathogens.
- Shows anti-inflammatory activity on Phorbol 12-myristate 13-acetate (PMA)-stimulated A549 cells by suppressing the secretion of IL-6, IL-8, MCP-1, and ICAM-1.
- Inhibits activation of NF-κB/AP-1 in PMA-stimulated A549 cells.
- Inhibits airway inflammation in Ovalbumins-induced mice with allergic asthma, reducing Th2 cytokines, MCP-1, IgE secretion, and eosinophil/macrophage influx.
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