Apexbio Technology LLC Mevastatin 73573-88-3 10mM (in 1mL DMSO)

Supplier:  Apexbio Technology LLC B17885.1

Mevastatin (CAS 73573-88-3) is a small-molecule inhibitor targeting 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase It is designed to inhibit cholesterol biosynthesis by competitively binding to the active site of HMG-CoA reductase thereby regulating lipid metabolism Mevastatin exerts its biological activity primarily through reversible competitive inhibition of HMG-CoA reductase In in vitro studies Mevastatin demonstrates strong inhibition of sterol biosynthesis from acetate incorporation with an IC50 value of approximately 1 nM It also inhibits cell proliferation in cultured cells arresting the growth of L cells at concentrations around 1 3 M Based on these pharmacological properties Mevastatin holds research potential in studies exploring cholesterol metabolism cellular proliferation cell cycle progression and lipid regulation mechanisms

Catalog No. 50-000-94364