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Medchemexpress LLC Mezigdomide | 2259648-80-9 | 99.16% | 50 MG
Supplier: Medchemexpress LLC HY12939550MG
Mezigdomide (CC-92480) is a cereblon E3 ubiquitin ligase modulating agent (CELMoD) that functions as a molecular glue. It exhibits high affinity to cereblon, leading to potent antimyeloma activity. It induces loss of Aiolos and Ikaros in PBMCs, activating T cells and increasing IL-2 and IFN-γ production.
- Functions as a molecular glue
- Exhibits high affinity to cereblon
- Potent antimyeloma activity
- Activates T cells and increases IL-2 and IFN-γ production
- Effective in resistant cell lines
- Induces apoptosis as a single agent
- Shows significant synergy with NSC 34521
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