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Medchemexpress LLC MHY1485 | 326914-06-1 | 99.9% | 200 MG
Supplier: Medchemexpress LLC HYB0795200MG
MHY1485 is a potent, cell-permeable mTOR activator that targets the ATP domain of mTOR. It inhibits autophagy by suppressing the fusion between autophagosomes and lysosomes.
- Inhibits GCDC-induced autophagic activity in HCC cells
- Increases LC3II/LC3I ratio in rat liver Ac2F cells
- Dose-dependently increases phosphorylation of mTOR at Ser2448 and upregulates 4E-BP1 phosphorylation in Ac2F cells
- Blocks autophagy signaling induced by follicle-stimulating hormone (FSH) in female ICR mice
- Increases p-mTOR and p-S6K1 expression levels in mice
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