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Medchemexpress LLC Minocycline hydrochloride | 13614-98-7 | 99.7% | 2 G
Supplier: Medchemexpress LLC HY174122G
Minocycline hydrochloride is an orally active, potent, and BBB-penetrated semi-synthetic tetracycline antibiotic. It is a hypoxia-inducible factor (HIF)-1α inhibitor. It exhibits anti-cancer, anti-inflammatory, and glutamate antagonist effects, reduces glutamate neurotransmission, and shows neuroprotective properties and antidepressant effects. It inhibits bacterial protein synthesis by binding with the 30S subunit of the bacterial ribosome, leading to a bacteriostatic effect.
- Suppresses proliferation and clonogenic activity in ovarian cancer cell lines.
- Arrests cell cycle by inhibiting cyclins and suppressing DNA incorporation.
- Induces cell apoptosis in ovarian cancer cell lines.
- Provides direct neuronal protection, preserving mitochondrial integrity.
- Suppresses hypoxia-inducible factor (HIF)-1α.
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